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Abstract

Background: Effect of additional supplementation of vitamin D toward Systemic lupus erythematosus (SLE) disease activity still differ in results obtained between studies being conducted. The current meta-analysis systematically analyzed the effect of vitamin D supplementation on SLE disease activity with updated literature, also its effect toward other parameters.


Material and Methods: Relevant literatures were obtained from PubMed database and Google Scholar. The obtained studies were analyzed using fixed effect model or random effect model.


Results: Five eligible studies with a total of 318 participants were included. Vitamin D supplementation did not affect the total SLEDAI score in SLE patients with pooled mean difference of -0.96 (p =0.09; 95% CI: -2.06 to 0.14). Serum vitamin D level increased after administration of vitamin D with pooled mean difference of 12.67 (p =0.001; 95% CI: 5.04 to 20.29). vitamin D supplementation increase serum calcium levels, with pooled difference of 0.07 (p = 0.006; 95% CI: 0.02 to 0.12). Pooled results from two studies obtained vitamin D supplementation did not affect ESR, C3 and C4.


Conclusions: Current meta-analysis obtained no significant changes in SLEDAI scores due to vitamin D supplementation. In contrast, serum vitamin D and serum calcium levels were increased.

Article Details

Author Biographies

G Kambayana, 1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Udayana University / Sanglah General Hospital, Denpasar, Bali, Indonesia

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia

Pande Ketut Kurniari, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Udayana University / Sanglah General Hospital, Denpasar, Bali, Indonesia

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia

Wira Gotera, Division of Endocrinology and Metabolic, Department of Internal Medicine, Faculty of Medicine, Udayana University / Sanglah General Hospital, Denpasar, Bali, Indonesia

Division of Endocrinology and Metabolic, Department of Internal Medicine, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia

Yenny Kandarini, Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Udayana University / Sanglah General Hospital, Denpasar, Bali, Indonesia

Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia

How to Cite
Kambayana, G., Sindhughosa, D. A., Kurniari, P. K., Gotera, W., & Kandarini, Y. (2021). Effect of Vitamin D Supplementation in Disease Activity, Activity-Related Markers, Inflammatory Marker and Serum Calcium of Systemic Lupus Erythematosus Patiens: A Systematic Review and Meta-Analysis . Indonesian Journal of Rheumatology, 13(1), 504-515. https://doi.org/10.37275/ijr.v13i1.168